ABSTRACT
Purpose@#The aim of this systematic literature review was to synthesize and investigate the effects of shift workers’sleep in Korea. @*Methods@#A search was conducted through three electronic databases using keywords such as “shift work” or “rotation work” and “sleep”, with sleep as the independent variable, and 17 papers were reviewed. @*Results@#The design of those 17 studies was analyzed in a cross-sectional analysis. The most commonly measured characteristic was quality of sleep, whereas the others were sleep disturbance, sleep efficiency, and sleepiness. The study outcome variables were job-related factors, mental health, wellness, stress, fatigue, and metabolic syndrome. @*Conclusion@#The results inform sleep and health-promoting behaviors and improvement in shift workers’working condition.
ABSTRACT
Purpose@#This study was conducted to identify the predictors of falls according to the fall risk level in general hospital inpatients. @*Methods@#Data were extracted from electronic medical records from January 2017 to December 2019. This study included 170 fallers and 340 non-fallers, who were matched for gender, age, clinical department, and length of stay before falls among inpatients aged 18 years and over. The collected data were analyzed with the x2 test, Fisher exact test, independent t-test, and logistic regression analysis using SPSS for Windows version 24.0. @*Results@#In the low-risk group, defecation disorder (odds ratio [OR]=12.49, 95% confidence interval [CI]=1.16~134.33, p=.037) and laxative use (OR=9.62, 95% CI=2.14~43.22, p=.003) were statistically significant risk factors for falls. In the medium-risk group, disorientation (OR=2.40, 95% CI=1.11~5.19, p=.026) was a statistically significant risk factor for falls. In the high-risk group, disorientation (OR=12.54, 95% CI=1.39~113.26, p=.024) and hypoglycemic agent use (OR=5.39, 95% CI=1.58~18.44, p=.007) were statistically significant risk factors for falls. @*Conclusion@#The results of this study show that risk factors for falls differed among the fall risk groups. It is necessary to use fall prevention strategies tailored to fall risk groups and fall risk assessment tools that have been revised accordingly.
ABSTRACT
Cancer-associated fibroblasts (CAFs) represent a major component of the tumor microenvironment and interplay with cancer cells by secreting cytokines, growth factors and extracellular matrix proteins. When estrogen receptor-negative breast cancer MDAMB-231 cells were treated with the CAF-conditioned medium (CAF-CM), Akt and STAT3 involved in cell proliferation and survival were activated through phosphorylation. CAFs secrete fibroblast growth factor 2 (FGF2), thereby stimulating breast cancer cell progression. Akt activation induced by CAF-CM in MDA-MB-231 cells was abolished when FGF2-neutralizing antibody was added.Treatment of MDA-MB-231 cells directly with FGF2 enhanced the phosphorylation of Akt and the FGF receptor (FGFR) substrate, FRS2α. These events were abrogated by siRNA-mediated silencing of FGFR1. In a xenograft mouse model, co-injection of MDAMB-231 cells with activated fibroblasts expressing FGF2 dramatically enhanced activation of Akt. Stable knockdown of FGFR1 blunted Akt phosphorylation in xenograft tumors. MDA-MB-231 cells co-cultured with CAFs or directly stimulated with FGF2 exhibited enhanced nuclear localization of FGFR1. Notably, FGF2 stimulation produced reactive oxygen species (ROS) accumulation in MDA-MB-231 cells, and FGF2-induced nuclear accumulation of FGFR1 was abrogated by the ROS scavenging agent, N-acetylcysteine.